The name could be of one or two origins. It could be a Corsican form of Alexandra or it could be a Latinate form of the Greek female name, Lysandra, which is a feminine form of Lysandros Λυσανδρος , which is composed of the Greek elements, λυσις lysis (to release) and ανδρος andros (man).

Lysandra was borne by a daughter of Ptolomy I Soter.

Lysandra is also the name of a genus of butterfly.

As of 2011, Lisandra was the 2nd most popular female name in Estonia.