The name is derived from the Mayan name, Ix Chel, which was the name of an important goddess of the moon, midwifery and the earth in Mayan culture. Its modern Spanish transliteration is Itzel or Itxel and it is currently a very popular female name in Mexico. Its meaning is uncertain but it has been suggested to be related to the Yucatan word chel (rainbow).
Currently, Itzel is the 411th most popular female name in the United States, (2010). Two other forms are Itxel and Ixchel.