The name is of a few different meanings and origins.
It could come directly from the Albanian meaning, “lioness.”
The name is found in several Romanian folktales as a name of a princess/heroine. In this case, the origins of the name are not clear.
It could be an Italian contraction of Luisa and Anna.
In Hawaiian, it comes directly from the word meaning “to be at leisure; to relax.”
Currently, in German-speaking Switzerland, it is the 21st most popular female name, (2010). Its popularity in Switzerland may be due to a popular Swiss rapper known simply as Luana.